Read e-book online Anticancer Agents from Natural Products, Second Edition PDF

By Gordon M. Cragg,David G. I. Kingston,David J. Newman

ISBN-10: 1439813825

ISBN-13: 9781439813829

The method of drug discovery from usual assets has yielded many vital new prescription drugs inaccessible by means of different routes. in lots of circumstances the remoted normal product will not be an efficient drug for any of a number of purposes, however it however might turn into a drug via chemical amendment or have a singular pharmacophore for destiny drug layout. In summarizing the prestige of normal items as melanoma chemotherapeutics, Anticancer brokers from usual items, moment Edition covers the:





  • History of every coated drug—a dialogue of its mechanism on motion, medicinal chemistry, synthesis, and scientific applications

  • Potential for novel drug discovery by utilizing genome mining in addition to destiny advancements in anticancer drug discovery

  • Important biosynthetic techniques to "unnatural" typical items



Anticancer brokers from traditional items, moment Edition discusses how complicated target-oriented synthesis—enabled via old advances in methodology—has greatly increased the scope of the potential. This ebook covers the present clinically used anticancer brokers which are both typical items or are in actual fact derived from average product leads. It additionally stories drug applicants at present in scientific improvement considering that lots of those might be clinically used medications sooner or later.



Examples contain the medication etoposide and teniposide derived from the lead compound podophyllotoxin; various analogs derived from taxol; topotecan, derived from camptothecin; and the unreal medical applicants, E7389 and HTI-286, built from the marine leads, halichondrin B and hemiasterlin.

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Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman


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